CTRB1 and LYPD3

Data Source:
HPRD (in vitro)

		CTRB1	LYPD3
Description		chymotrypsinogen B1	LY6/PLAUR domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity	Laminin Binding
	Biological Process	Proteolysis Digestion Cobalamin Metabolic Process Extracellular Matrix Disassembly	Cell-matrix Adhesion
Pathways		Activation of Matrix Metalloproteinases Cobalamin (Cbl, vitamin B12) transport and metabolism	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Trans-O-Hydroxy-Alpha-Methyl Cinnamate 2,4-Dihydroxy-Trans Cinnamic Acid Phenylethane Boronic Acid Phosphorylisopropane Aprotinin 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE alpha-Methyl-2-hydroxy-4-diethylaminocinnamic acid 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE (2S) N-acetyl-L-alanyl-Î±L-phenylalanyl-chloroethylketone 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Phenylalanylmethylchloride L-1-naphthyl-2-acetamido-ethane boronic acid D-1-naphthyl-2-acetamido-ethane boronic acid D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Pancreatic cancer ( 25086665) Type 2 diabetes ( 30054458)	Cotinine glucuronidation ( 25293881)
Interacting Genes		4 interacting genes: LYPD3 SERPINA1 SERPINA3 SERPINF2	17 interacting genes: AGR2 AGR3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11
Entrez ID		1504	27076
HPRD ID		00345	10783
Ensembl ID		ENSG00000168925	ENSG00000124466
Uniprot IDs		P17538	B2RBR3 O95274
PDB IDs			6IOM 6ION
Enriched GO Terms of Interacting Partners?
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