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LYPD3 and PTPRJ
Data Source:
BioGRID
(two hybrid)
LYPD3
PTPRJ
Description
LY6/PLAUR domain containing 3
protein tyrosine phosphatase receptor type J
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Integral Component Of Membrane
Anchored Component Of Plasma Membrane
Immunological Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Ruffle Membrane
Specific Granule Membrane
Extracellular Exosome
Molecular Function
Laminin Binding
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Beta-catenin Binding
Phosphatase Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Mitogen-activated Protein Kinase Binding
Delta-catenin Binding
Biological Process
Cell-matrix Adhesion
Protein Dephosphorylation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Cell Adhesion
B Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Positive Regulation Of Tumor Necrosis Factor Production
Peptidyl-tyrosine Dephosphorylation
Calcium-mediated Signaling Using Intracellular Calcium Source
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Vascular Permeability
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Adhesion
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Contact Inhibition
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways
Post-translational modification: synthesis of GPI-anchored proteins
Phosphorylation of CD3 and TCR zeta chains
Neutrophil degranulation
Negative regulation of MET activity
Negative regulation of FLT3
Drugs
Diseases
GWAS
Cotinine glucuronidation (
25293881
)
Acute lymphoblastic leukemia (childhood) (
22076464
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Blood protein levels (
30072576
)
D-dimer levels (
21502573
)
Experiencing mood swings (
29500382
)
Heel bone mineral density (
30598549
)
Height (
28552196
25282103
23563607
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hypertension (
31879980
)
Intraocular pressure (
29617998
25173106
31798171
29785010
31959993
30054594
29235454
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Sleep duration (short sleep) (
30846698
)
Interacting Genes
17 interacting genes:
AGR2
AGR3
AURKA
BAG4
BRMS1
CASP8
CHEK2
CTRB1
ERBB2
IGF1R
LSP1
PALB2
PPM1D
PTPRJ
RB1CC1
SMAD4
STK11
36 interacting genes:
ANP32B
BAAT
BAP1
CASC3
CTNNB1
CTNND1
CYP17A1
EGFR
EPSTI1
FANCC
FBP1
HEMGN
HOXC6
HRAS
IL2RG
JUP
KLK7
KLK9
LAT
LYPD3
MAP2K1
MET
NANS
NOP2
PDGFRB
PLCG1
PPP2CB
PPP3R2
PRDM14
RASA1
SDCBP
SFRP4
TMEFF1
TRMO
TSTD2
ZNF510
Entrez ID
27076
5795
HPRD ID
10783
02955
Ensembl ID
ENSG00000124466
ENSG00000149177
Uniprot IDs
B2RBR3
O95274
Q12913
Q9NPR5
PDB IDs
6IOM
6ION
2CFV
2DLE
2NZ6
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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