GNAI1 and CNR1

Data Source:
HPRD (in vivo)

		GNAI1	CNR1
Description		G protein subunit alpha i1	cannabinoid receptor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region	Cytoplasm Mitochondrial Outer Membrane Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Growth Cone Integral Component Of Mitochondrial Membrane Membrane Raft Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Drug Binding Identical Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Protein Folding Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Negative Regulation Of Serotonin Secretion Regulation Of Metabolic Process Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection Retrograde Trans-synaptic Signaling By Endocannabinoid Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion	Dronabinol Nabilone Ricinoleic Acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)	Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)
Interacting Genes		62 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GNG2 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	8 interacting genes: GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Entrez ID		2770	1268
HPRD ID		00756	00259
Ensembl ID		ENSG00000127955	ENSG00000118432
Uniprot IDs		P63096	P21554 S5TLS4 V5KA96
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM	1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B
Enriched GO Terms of Interacting Partners?
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