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ADRB1
Description
adrenoceptor beta 1
Image
GO Annotations
Cellular Component
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Schaffer Collateral - CA1 Synapse
Molecular Function
G Protein-coupled Receptor Activity
Beta-adrenergic Receptor Activity
Beta1-adrenergic Receptor Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
PDZ Domain Binding
Alpha-2A Adrenergic Receptor Binding
Protein Heterodimerization Activity
G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential
Biological Process
Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine
Diet Induced Thermogenesis
Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Response To Cold
Heat Generation
Negative Regulation Of Multicellular Organism Growth
Fear Response
Positive Regulation Of GTPase Activity
Regulation Of Circadian Sleep/wake Cycle, Sleep
Brown Fat Cell Differentiation
Regulation Of Postsynaptic Membrane Potential
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Adrenoceptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Spermine
Amphetamine
Esmolol
Betaxolol
Bethanidine
Isoetharine
Ranolazine
Cabergoline
Metoprolol
Olanzapine
Atenolol
Norepinephrine
Timolol
Phenylpropanolamine
Loxapine
Sotalol
Carteolol
Nortriptyline
Lamotrigine
Propranolol
Labetalol
Bisoprolol
Epinephrine
Paroxetine
Trimipramine
Cryptenamine
Dobutamine
Pseudoephedrine
Alprenolol
Terbutaline
Salmeterol
Pindolol
Formoterol
Salbutamol
Ergoloid mesylate
Isoprenaline
Arbutamine
Amiodarone
Carvedilol
Desipramine
Propafenone
Acebutolol
Nadolol
Levobunolol
Metipranolol
Aripiprazole
Fenoterol
Pirbuterol
Bevantolol
Practolol
Penbutolol
Ephedra sinica root
Ephedrine
Mephentermine
Clenbuterol
Oxprenolol
Putrescine
Spermidine
Celiprolol
Dronedarone
Nebivolol
Asenapine
Droxidopa
Bufuralol
4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Bopindolol
Bupranolol
Befunolol
Vortioxetine
Arotinolol
Levobetaxolol
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
DL-Methylephedrine
Dihydroergocristine
Xamoterol
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Birth weight (
23202124
31043758
27680694
)
Blood pressure (
21909110
)
Diastolic blood pressure (
28135244
27841878
28739976
27618452
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Gaucher disease severity (
22388998
)
HDL cholesterol levels (
32203549
)
High density lipoprotein cholesterol levels (
29083408
)
LDL cholesterol levels (
32203549
)
Lipid traits (pleiotropy) (HIPO component 1) (
30289880
)
Mean arterial pressure (
27618448
)
Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Mean arterial pressure x alcohol consumption interaction (2df test) (
29912962
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Platelet distribution width (
32888494
)
PR interval (
32439900
)
Systolic blood pressure (
27841878
28739976
27618447
27618452
30578418
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Triglyceride levels (
32203549
)
Interacting Genes
16 interacting genes:
ADRA2A
ARRB1
DLG1
DLG4
DLGAP2
GIPC1
GOPC
GPRASP1
GPRASP2
GRB2
MAGI2
MAGI3
NOS1
SH3GL2
SH3GL3
SNTA1
Entrez ID
153
HPRD ID
00181
Ensembl ID
ENSG00000043591
Uniprot IDs
P08588
PDB IDs
2LSQ
Enriched GO Terms of Interacting Partners
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