CTNNA1 and FRAT2

Data Source:
BioGRID (two hybrid)

		CTNNA1	FRAT2
Description		catenin alpha 1	FRAT regulator of WNT signaling pathway 2
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Flotillin Complex Lamellipodium Cell Junction Intracellular Membrane-bounded Organelle	Cellular_component Cytoplasm Cytosol
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	Molecular_function
	Biological Process	Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Beta-catenin Destruction Complex Disassembly
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Malaria ( 31844061) Schizophrenia ( 25056061)	Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		52 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APC APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS OBI1 PKD1 PSEN1 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510	12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12
Entrez ID		1495	23401
HPRD ID		00285	05419
Ensembl ID		ENSG00000044115	ENSG00000181274
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	O75474
PDB IDs		1H6G 4EHP 4IGG 6UPV 6V2O 6V2P
Enriched GO Terms of Interacting Partners?
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