FRAT2 and MLH3

Data Source:
BioGRID (two hybrid)

		FRAT2	MLH3
Description		FRAT regulator of WNT signaling pathway 2	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Molecular_function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Beta-catenin Destruction Complex Disassembly	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12	45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		23401	27030
HPRD ID		05419	05094
Ensembl ID		ENSG00000181274	ENSG00000119684
Uniprot IDs		O75474	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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