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FRAT2 and EGFR
Data Source:
BioGRID
(two hybrid)
FRAT2
EGFR
Description
FRAT regulator of WNT signaling pathway 2
epidermal growth factor receptor
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Cytoplasm
Cytosol
Golgi Membrane
Extracellular Space
Nucleus
Cytoplasm
Endosome
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Basal Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Cell Junction
Endocytic Vesicle
Clathrin-coated Vesicle Membrane
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Receptor Complex
Membrane Raft
Synapse
Perinuclear Region Of Cytoplasm
Shc-EGFR Complex
Multivesicular Body, Internal Vesicle Lumen
Molecular Function
Molecular_function
Virus Receptor Activity
Chromatin Binding
Double-stranded DNA Binding
MAP Kinase Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Epidermal Growth Factor-activated Receptor Activity
Integrin Binding
Protein Binding
Calmodulin Binding
ATP Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Protein Phosphatase Binding
Nitric-oxide Synthase Regulator Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Cadherin Binding
Epidermal Growth Factor Binding
Actin Filament Binding
ATPase Binding
Biological Process
Beta-catenin Destruction Complex Disassembly
MAPK Cascade
Activation Of MAPKK Activity
Ossification
Positive Regulation Of Protein Phosphorylation
Hair Follicle Development
Regulation Of Transcription By RNA Polymerase II
Translation
Response To Osmotic Stress
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Multicellular Organism Development
Midgut Development
Learning Or Memory
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Nitric Oxide Mediated Signal Transduction
Magnesium Ion Homeostasis
Regulation Of Phosphatidylinositol 3-kinase Signaling
Diterpenoid Metabolic Process
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Cobalamin
Response To Hydroxyisoflavone
Positive Regulation Of Kinase Activity
Cellular Response To Reactive Oxygen Species
Cellular Response To Drug
Peptidyl-tyrosine Autophosphorylation
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Wound Healing
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Phosphorylation
Ovulation Cycle
Hydrogen Peroxide Metabolic Process
Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Tongue Development
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Bone Resorption
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Vasoconstriction
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Viral Entry Into Host Cell
Protein Autophosphorylation
Astrocyte Activation
Positive Regulation Of Smooth Muscle Cell Proliferation
Neuron Projection Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Inflammatory Response
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Nitric-oxide Synthase Activity
Protein Insertion Into Membrane
Response To Calcium Ion
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synaptic Transmission, Glutamatergic
Membrane Organization
Response To UV-A
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Dexamethasone Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Liver Regeneration
Cell-cell Adhesion
Positive Regulation Of Protein Kinase C Activity
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of ERBB Signaling Pathway
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Prolactin Secretion
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Negative Regulation Of Cardiocyte Differentiation
Regulation Of Cell Motility
Pathways
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
Signal transduction by L1
Constitutive Signaling by EGFRvIII
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Extra-nuclear estrogen signaling
NOTCH3 Activation and Transmission of Signal to the Nucleus
HCMV Early Events
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Cetuximab
Lidocaine
Gefitinib
Erlotinib
Lapatinib
Panitumumab
Alvocidib
IGN311
Matuzumab
Vandetanib
Rindopepimut
Canertinib
Pelitinib
Varlitinib
AV-412
S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
PD-168393
Afatinib
Osimertinib
Necitumumab
Foreskin keratinocyte (neonatal)
Depatuxizumab mafodotin
Icotinib
Neratinib
Dacomitinib
Fostamatinib
Zalutumumab
Brigatinib
Olmutinib
Zanubrutinib
Abivertinib
Diseases
Choriocarcinoma
Gastric cancer
Bladder cancer
Oral cancer
Glioma
Laryngeal cancer
Cervical cancer
Esophageal cancer
GWAS
Body mass index (
28892062
)
General risk tolerance (MTAG) (
30643258
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Glioblastoma (
28346443
29743610
)
Glioblastoma (age-stratified) (
30152087
)
Glioma (
28346443
21531791
29743610
)
Impulsivity (
30718321
)
Initial alcohol sensitivity (
30276832
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Non-glioblastoma glioma (
28346443
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Refractive astigmatism (
30306274
)
Subjective response to lithium treatment (
26503763
)
Interacting Genes
12 interacting genes:
BUB1
CDKN2A
CTNNA1
EGFR
ERBB2
GSK3B
KRAS
MCC
MLH1
MLH3
NRAS
PTPN12
409 interacting genes:
ABL2
ACTA1
ADRM1
AGTR1
AHNAK
AHSA1
AIP
AKAP12
ALCAM
ALDOA
AMH
ANKS1A
ANKS1B
ANXA1
AOPEP
AP2B1
APBA3
APBB1
APBB3
APP
APPL1
AR
AREG
ARF4
ARHGEF12
ARHGEF7
ARRB2
ATIC
ATP1A1
ATP1B1
ATP5F1C
AXL
B4GALT1
BAIAP2
BCAR3
BLK
BLNK
BMX
BTC
CALM1
CALM2
CALM3
CAMK2A
CAMK2G
CAMLG
CASP1
CAV1
CAV2
CAV3
CBL
CBLB
CBLC
CCDC88A
CD44
CD59
CD82
CDC25A
CDC34
CDH1
CDH5
CDK1
CEACAM1
CEBPB
CEND1
CFL1
CLNK
CLTA
CLTCL1
CMTM8
CNOT9
CNTN2
COL9A3
CRK
CSRP1
CTNNB1
CTNND1
CTTN
CYLC2
DCBLD2
DCN
DCTN2
DEGS1
DNAJC4
DOK2
DOK4
DOK5
DOK6
DUSP19
DUSP3
DYNC1H1
EGF
ELF3
EPB41
EPHA2
EPPK1
EPS15
EPS8
ERBB2
ERBB3
ERBB4
EREG
ERRFI1
ESR1
EZR
FAH
FANCC
FAS
FBXO25
FER
FES
FGR
FKBP4
FKBP8
FN1
FRAT2
FRK
GAB1
GABARAPL2
GAPDH
GGA1
GGA3
GJB1
GNAI2
GNAS
GOT1
GPM6B
GPNMB
GRAP2
GRB10
GRB14
GRB2
GRB7
GRIN2B
GRK2
H3-4
HBEGF
HCK
HDAC6
HDAC7
HEMGN
HEXIM1
HGS
HOXC10
HPN
HSH2D
HSP90AA1
HSP90AB1
HSP90B1
HSPA1A
HSPA4
HSPA8
HTT
ICAM1
IKBKG
IL13RA2
IL5RA
ILKAP
INPPL1
IQGAP1
IRS1
IRS4
ITGA5
ITGB1
ITGB2
ITK
ITSN2
JAK2
JUP
KCTD9P2
KEAP1
KRT17
KRT18
KRT7
KRT8
LAT
LCK
LCP2
LINC01139
LRP1
LRRK1
LYN
MAP2K1
MAP3K12
MAP3K14
MAP3K3
MAP4K1
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
MAPT
MAST1
MATR3
MDH1
MEGF6
MET
MGARP
MIF
MOB4
MT-CO2
MTDH
MUC1
MUC4
NANS
NCAM1
NCK1
NCK2
NDN
NEDD4
NF2
NIBAN2
NR3C1
NRG1
NTRK2
NUMB
NUMBL
OAZ1
OLFM1
PAK1
PCNA
PDCD6IP
PDGFRA
PDGFRB
PDK3
PDP1
PFKP
PIK3C2A
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PIM1
PIN4
PITPNA
PKIA
PLCG1
PLCG2
PLD1
PLD2
PLEC
PLSCR1
PML
PPARG
PPM1A
PPM1B
PPP2CB
PPP3CB
PPP5C
PRCC
PRDX1
PRKACA
PRKAR1A
PRKAR1B
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKD1
PSMA7
PSMD4
PTGDS
PTK2
PTK2B
PTK6
PTPN1
PTPN11
PTPN12
PTPN18
PTPN2
PTPN20
PTPN22
PTPN6
PTPN7
PTPRB
PTPRH
PTPRJ
PTPRR
PTPRS
PTPRT
PTPRU
RAB31
RAB3A
RAF1
RAP1GDS1
RAPGEF1
RASA1
RGS16
RGS2
RGS4
RIN1
RIN2
RIPK1
RNF115
RNF126
RNF144A
RRAD
RUSC2
S100A4
S100A7
S100A9
SCAMP1
SCAMP3
SEC13
SELENOP
SFN
SGSM2
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH3BGRL3
SH3GL3
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SHE
SLA
SLA2
SLC3A2
SLC9A3R1
SMURF2
SNCA
SNRPD2
SNX1
SNX2
SNX4
SNX6
SNX9
SOCS1
SOCS2
SOCS3
SOCS4
SOCS5
SOCS6
SOCS7
SORBS2
SOS1
SOS2
SPARCL1
SPCS2
SRC
STAM2
STAP1
STAP2
STAT1
STAT2
STAT3
STAT5A
STAT5B
STIP1
STX17
STYX
SUPT6H
SYK
TAB1
TEC
TGFA
TGFB1
TJP1
TLN1
TLR2
TMCO3
TNC
TNFRSF1A
TNK2
TNS1
TNS2
TNS3
TNS4
TPI1
TPM1
TRAF2
TRMO
TRPV1
TSTD2
TUBA1A
TUBA4A
TXK
TXN
UBB
UBE2V2
UCHL1
UROD
VAPA
VAV1
VAV2
VAV3
WASF3
WASL
XRCC6
YES1
YWHAB
YWHAQ
YWHAZ
ZAP70
ZNF510
ZPR1
Entrez ID
23401
1956
HPRD ID
05419
00579
Ensembl ID
ENSG00000181274
ENSG00000146648
Uniprot IDs
O75474
B7Z2I3
E7BSV0
E9PFD7
F2YGG7
P00533
Q504U8
PDB IDs
1DNQ
1DNR
1IVO
1M14
1M17
1MOX
1NQL
1XKK
1YY9
1Z9I
2EB2
2EB3
2EXP
2EXQ
2GS2
2GS6
2GS7
2ITN
2ITO
2ITP
2ITQ
2ITT
2ITU
2ITV
2ITW
2ITX
2ITY
2ITZ
2J5E
2J5F
2J6M
2JIT
2JIU
2JIV
2KS1
2M0B
2M20
2N5S
2RF9
2RFD
2RFE
2RGP
3B2U
3B2V
3BEL
3BUO
3C09
3G5V
3G5Y
3GOP
3GT8
3IKA
3LZB
3NJP
3OB2
3OP0
3P0Y
3PFV
3POZ
3QWQ
3UG1
3UG2
3VJN
3VJO
3VRP
3VRR
3W2O
3W2P
3W2Q
3W2R
3W2S
3W32
3W33
4G5J
4G5P
4HJO
4I1Z
4I20
4I21
4I22
4I23
4I24
4JQ7
4JQ8
4JR3
4JRV
4KRL
4KRM
4KRO
4KRP
4LI5
4LL0
4LQM
4LRM
4R3P
4R3R
4R5S
4RIW
4RIX
4RIY
4RJ4
4RJ5
4RJ6
4RJ7
4RJ8
4TKS
4UIP
4UV7
4WD5
4WKQ
4WRG
4ZAU
4ZJV
4ZSE
5C8K
5C8M
5C8N
5CAL
5CAN
5CAO
5CAP
5CAQ
5CAS
5CAU
5CAV
5CNN
5CNO
5CZH
5CZI
5D41
5EDP
5EDQ
5EDR
5EM5
5EM6
5EM7
5EM8
5FED
5FEE
5FEQ
5GMP
5GNK
5GTY
5GTZ
5HCX
5HCY
5HCZ
5HG5
5HG7
5HG8
5HG9
5HIB
5HIC
5J9Y
5J9Z
5JEB
5LV6
5SX4
5SX5
5U8L
5UG8
5UG9
5UGA
5UGB
5UGC
5UWD
5WB7
5WB8
5X26
5X27
5X28
5X2A
5X2C
5X2F
5X2K
5XDK
5XDL
5XGM
5XGN
5XWD
5Y25
5Y9T
5YU9
5ZTO
5ZWJ
6ARU
6B3S
6D8E
6DUK
6JRJ
6JRK
6JRX
6JWL
6JX0
6JX4
6JXT
6JZ0
6LUB
6LUD
6P1D
6P1L
6P8Q
6S89
6S8A
6S9B
6S9C
6S9D
6TFU
6TFV
6TFW
6TFY
6TFZ
6TG0
6TG1
6V5N
6V5P
6V66
6V6K
6V6O
6VH4
6VHN
6VHP
Enriched GO Terms of Interacting Partners
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