CSTA and CD86

Data Source:
HPRD (two hybrid)

		CSTA	CD86
Description		cystatin A	CD86 molecule
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cornification Cell-cell Adhesion	Adaptive Immune Response Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity
Pathways		Formation of the cornified envelope	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 25972035 29403010 20705733)	Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		12 interacting genes: CTSB CTSH CTSL DSP EVPL IVL KRT1 LORICRIN PI3 PTN UCHL5 ZDHHC17	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		1475	942
HPRD ID		01697	03011
Ensembl ID		ENSG00000121552	ENSG00000114013
Uniprot IDs		P01040	A0A0X9R4E0 A8K632 P42081
PDB IDs		1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE	1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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