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CSNK2B and SHANK3
Data Source:
BioGRID
(two hybrid)
CSNK2B
SHANK3
Description
casein kinase 2 beta
SH3 and multiple ankyrin repeat domains 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
PcG Protein Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Cytosol
Ionotropic Glutamate Receptor Complex
Postsynaptic Density
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuron Projection
Dendritic Spine
Neuron Spine
Postsynaptic Membrane
Ciliary Membrane
Molecular Function
Chromatin Binding
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Protein Kinase Regulator Activity
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Actin Binding
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SH3 Domain Binding
Synaptic Receptor Adaptor Activity
Ionotropic Glutamate Receptor Binding
Protein Self-association
Scaffold Protein Binding
Biological Process
Protein Folding
Phosphatidylcholine Biosynthetic Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Wnt Signaling Pathway
Macroautophagy
Peptidyl-threonine Phosphorylation
Positive Regulation Of Activin Receptor Signaling Pathway
Adiponectin-activated Signaling Pathway
Cellular Protein-containing Complex Assembly
Neutrophil Degranulation
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Protein Kinase Activity
Regulation Of DNA Binding
Endothelial Tube Morphogenesis
Regulation Of Signal Transduction By P53 Class Mediator
MAPK Cascade
Axon Guidance
Synapse Assembly
Behavior
Learning
Memory
Striatal Medium Spiny Neuron Differentiation
Adult Behavior
Negative Regulation Of Actin Filament Bundle Assembly
Social Behavior
Vocal Learning
Negative Regulation Of Cell Volume
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Brain Morphogenesis
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Synapse Structural Plasticity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Vocalization Behavior
Postsynaptic Density Assembly
AMPA Glutamate Receptor Clustering
NMDA Glutamate Receptor Clustering
Guanylate Kinase-associated Protein Clustering
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Glutamate Receptor Signaling Pathway
Regulation Of Long-term Synaptic Depression
Regulation Of AMPA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of AMPA Receptor Activity
Pathways
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Drugs
ATP
Quercetin
Diseases
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Cutaneous lupus erythematosus (
25827949
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Systemic lupus erythematosus (
26316170
)
Ulcerative colitis (
28067908
)
Blood protein levels (
30072576
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Extremely high intelligence (
29520040
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Intelligence (MTAG) (
29326435
)
Mean platelet volume (
32888494
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Platelet count (
32888494
)
Interacting Genes
223 interacting genes:
ABHD4
ACTB
ACTL6B
ACTR1B
ACTR5
ACVRL1
ADD1
ADH5
ANGPT2
ANKRD28
AP2M1
APLP1
ARAF
ATF1
ATG101
ATXN3
BAG6
BANP
BCCIP
BHLHE41
BID
BMI1
BRCA1
BTF3
C6orf136
CACNA1A
CALM1
CBX4
CCDC115
CCDC187
CCNH
CD163
CD81
CDC25B
CDC34
CDK1
CDK20
CDKN1A
CENPB
CHEK1
CHRNA4
CIC
CIPC
CLOCK
COIL
COL4A2
COPS3
COPS7A
CPNE7
CSN1S1
CSN2
CSNK1E
CSNK2A1
CSNK2A2
CST1
CTDP1
CTNNB1
DACT1
DALRD3
DELEC1
DENND5A
DNMT1
DPF3
DUX1
DYNLT2B
EIF2S2
EIF5
EIF6
EPS8
ERCC6
ERCC8
ESR1
FAF1
FAM86C1P
FBXL15
FBXL5
FGB
FGF1
FGF2
FIBP
FKBP3
FTH1
GADD45GIP1
GAMT
GBP2
GLB1
GLIS2
GNB5
GRK2
GSK3B
HEXB
HIRIP3
HNRNPA2B1
HOXB5
HOXB6
HTRA1
HYPK
IER3IP1
INO80B
INTS11
IRS1
ITSN1
KDM6B
KIF2C
LCK
LEPR
LMO4
LRP5L
LTB4R2
LYN
LYST
MAPK14
MBD4
MDM2
MME
MOXD1
MPP2
NAP1L1
NCF1
NGDN
NMT2
NOLC1
NOTCH3
NPAS2
NRBP1
NRF1
NTAQ1
ODC1
OGA
OGT
PDS5A
PER1
PER2
PFKFB4
PHC2
PHF11
PHRF1
PIMREG
PIN1
PITPNA
PLXNA3
POT1
PPID
PPP1CA
PPP1CB
PPP1CC
PPP2CA
PPP2R1A
PPP2R1B
PPP2R5D
PPP2R5E
PPP3CC
PRKAB2
PRKCZ
PRNP
PROC
PTPRK
PTTG2
PYROXD2
RAD51
RBM39
RFC1
RNF126
RNF7
RORB
RPA1
RPL13
RPL41
RPL5
RPS6KA5
RPS6KB1
RPS6KB2
RRAD
RXRA
SARNP
SDHA
SEC11A
SELENOI
SHANK3
SHMT1
SHMT2
SIMC1
SIRT1
SNX2
SPOUT1
SPSB3
SSB
STAT5A
STAU1
STK16
SUMO2
SYNE4
TCEAL7
TENM1
TFAP2A
TFAP2D
TLE1
TLX3
TNFAIP1
TOP2B
TP53
TP53BP2
TP63
TRIM54
TSEN54
TUBB2B
TWF1
UBE2I
UPF1
USO1
UTP14A
VDAC1
VRK3
WDR1
WDR18
WFIKKN1
WWOX
ZNF19
ZNF410
ZNF44
ZNF71
ZNF784
ZNHIT1
17 interacting genes:
ABCC2
CNKSR2
COPS5
CRKL
CSNK2B
DLGAP1
DLGAP2
DLGAP3
DLGAP4
GRB2
MAPK1
NCK1
PAX6
PPP1CC
RPS6KA1
SPTAN1
USP8
Entrez ID
1460
85358
HPRD ID
00278
18979
Ensembl ID
ENSG00000204435
ENSG00000251322
Uniprot IDs
A0A1U9X7J2
N0E4C7
P67870
PDB IDs
1DS5
1JWH
1QF8
3EED
4DGL
4MD7
4MD8
4MD9
4NH1
6Q38
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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