SHANK3 and ABCC2

Data Source:
BioGRID (two hybrid)

		SHANK3	ABCC2
Description		SH3 and multiple ankyrin repeat domains 3	ATP binding cassette subfamily C member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Ionotropic Glutamate Receptor Complex Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus Intracellular Canaliculus
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Protein Self-association Scaffold Protein Binding	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	MAPK Cascade Axon Guidance Synapse Assembly Behavior Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity	Drug Transmembrane Transport Inflammatory Response Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Cellular Response To Drug Bile Acid Signaling Pathway Xenobiotic Catabolic Process Response To Estrogen Drug Export Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Response To Antineoplastic Agent Regulation Of Bile Acid Secretion Transport Across Blood-brain Barrier Benzylpenicillin Metabolic Process Response To 17alpha-ethynylestradiol Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier
Pathways			Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS
Drugs			ATP Sulfinpyrazone
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748) Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1
Entrez ID		85358	1244
HPRD ID		18979	03065
Ensembl ID		ENSG00000251322	ENSG00000023839
Uniprot IDs			Q92887
PDB IDs
Enriched GO Terms of Interacting Partners?
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