MIB2 and ACTC1

Data Source:
HPRD (in vitro, two hybrid)

		MIB2	ACTC1
Description		MIB E3 ubiquitin protein ligase 2	actin alpha cardiac muscle 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome Cytosol	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Protein Polyubiquitination Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)	Axial length ( 24144296) Refractive error ( 32231278 20835239)
Interacting Genes		10 interacting genes: ACTA1 ACTC1 BCL10 GRIN2B JAG2 SRPK2 TBK1 UBE2D2 UBE2N UBE2U	41 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		142678	70
HPRD ID		15905	00015
Ensembl ID		ENSG00000197530	ENSG00000159251
Uniprot IDs		Q96AX9	B3KPP5 P68032
PDB IDs
Enriched GO Terms of Interacting Partners?
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