ACTC1 and ABRA

Data Source:
HPRD (in vivo)

		ACTC1	ABRA
Description		actin alpha cardiac muscle 1	actin binding Rho activating protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Plasma Membrane Actin Cytoskeleton Sarcomere
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Protein Binding
	Biological Process	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Protein Import Into Nucleus Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)	Dental caries ( 23259602) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Intraocular pressure ( 31959993 30054594) Metabolite levels ( 23823483)
Interacting Genes		41 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	6 interacting genes: ABLIM2 ACTA1 ACTB ACTC1 PPP1R18 TRAPPC2
Entrez ID		70	137735
HPRD ID		00015	11608
Ensembl ID		ENSG00000159251	ENSG00000174429
Uniprot IDs		B3KPP5 P68032	Q8N0Z2
PDB IDs
Enriched GO Terms of Interacting Partners?
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