MIB2 and JAG2

Data Source:
BioGRID (pull down)

		MIB2	JAG2
Description		MIB E3 ubiquitin protein ligase 2	jagged canonical Notch ligand 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome Cytosol	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Protein Polyubiquitination Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Skeletal System Development In Utero Embryonic Development Respiratory System Process Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)	Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ACTA1 ACTC1 BCL10 GRIN2B JAG2 SRPK2 TBK1 UBE2D2 UBE2N UBE2U	8 interacting genes: ATN1 ATXN7 CACNA1A GFI1B MIB2 NOTCH1 NOTCH2 NOTCH3
Entrez ID		142678	3714
HPRD ID		15905	03981
Ensembl ID		ENSG00000197530	ENSG00000184916
Uniprot IDs		Q96AX9	Q9Y219
PDB IDs			5MW5 5MW7 5MWF
Enriched GO Terms of Interacting Partners?
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