SIRPA and KRT2

Data Source:
BioGRID (pull down)

		SIRPA	KRT2
Description		signal regulatory protein alpha	keratin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Cornified Envelope Extracellular Space Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Protein Phosphorylation Cell Adhesion Regulation Of Gene Expression Cell Migration Regulation Of Interferon-gamma Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Positive Regulation Of T Cell Activation Leukocyte Migration Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of I-kappaB Phosphorylation	Keratinocyte Development Epidermis Development Peptide Cross-linking Keratinization Keratinocyte Activation Keratinocyte Proliferation Intermediate Filament Organization Positive Regulation Of Epidermis Development Keratinocyte Migration Cornification
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	Keratinization Formation of the cornified envelope
Drugs			Zinc Copper Anthralin Zinc acetate
Diseases			Ichthyosis bullosa of Siemens
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576 29875488) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 22139419 19820697 32888494 27863252) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM	15 interacting genes: EVPL KRT13 KRT15 KRT16 KRT19 KRT25 KRT27 KRT31 KRT33B KRT35 KRT36 KRT38 KRT40 SIRPA SMAD3
Entrez ID		140885	3849
HPRD ID		03912	02560
Ensembl ID		ENSG00000198053	ENSG00000172867
Uniprot IDs		P78324	P35908
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV
Enriched GO Terms of Interacting Partners?
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