SIRPA and TBX3

Data Source:
BioGRID (pull down)

		SIRPA	TBX3
Description		signal regulatory protein alpha	T-box transcription factor 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Chromatin Nucleus
	Molecular Function	SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cell Adhesion Regulation Of Gene Expression Cell Migration Regulation Of Interferon-gamma Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Positive Regulation Of T Cell Activation Leukocyte Migration Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of I-kappaB Phosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Blood Vessel Development In Utero Embryonic Development Cell Fate Specification Heart Looping Outflow Tract Morphogenesis Atrioventricular Bundle Cell Differentiation Cardiac Chamber Development Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Aging Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Animal Organ Morphogenesis Specification Of Animal Organ Position Stem Cell Population Maintenance Limbic System Development Male Genitalia Development Female Genitalia Development Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development Luteinizing Hormone Secretion Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Follicle-stimulating Hormone Secretion Mesoderm Morphogenesis Smooth Muscle Cell Differentiation Roof Of Mouth Development Ventricular Septum Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Placode Formation Cardiac Muscle Cell Fate Commitment Sinoatrial Node Cell Development Ureteric Peristalsis Cellular Senescence Positive Regulation Of Stem Cell Proliferation
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases			Ulnar-mammary syndrome; Schinzel syndrome
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576 29875488) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 22139419 19820697 32888494 27863252) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Atrial fibrillation ( 29892015) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21572416 21909110) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Breast cancer ( 29059683) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 26390057 28135244 19430479 27841878 29403010 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Facial morphology ( 31763980) FEV1 ( 30804560) Global electrical heterogeneity phenotypes ( 29622589) Heel bone mineral density ( 30598549 28869591) Hematological and biochemical traits ( 31902109) Hypertension ( 30487518) Idiopathic dilated cardiomyopathy ( 29495422) Ischemic stroke ( 29531354) Left ventricular QRS voltage ( 27195777) Longevity ( 30294719) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082 30804560) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Night sleep phenotypes ( 27126917) Nose morphology ( 29921221) Percent mammographic density ( 22532574) PR interval ( 30679814 30046033 32439900 20062060 25035420) PR segment ( 24850809) Prostate-specific antigen levels ( 28139693) QRS complex (12-leadsum) ( 27659466) QRS duration ( 30679814 27577874) Serum prostate-specific antigen levels ( 21160077) Stroke ( 29531354) Systolic blood pressure ( 27841878 29403010 27618452 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels in overweight individuals ( 25811787)
Interacting Genes		60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM	14 interacting genes: CA8 CSF3 PFDN5 PLEKHF2 PRR20A PRR20B PRR20C PRR20D PRR20E SIRPA TLE5 TOLLIP UFSP1 ZNF34
Entrez ID		140885	6926
HPRD ID		03912	03373
Ensembl ID		ENSG00000198053	ENSG00000135111
Uniprot IDs		P78324	A0A024RBL6 A0A024RBQ4 O15119
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV	1H6F
Enriched GO Terms of Interacting Partners?
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