DYNLL2 and KANK2

Data Source:
BioGRID (two hybrid)

		DYNLL2	KANK2
Description		dynein light chain LC8-type 2	KN motif and ankyrin repeat domains 2
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Postsynaptic Density Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Cytoplasm Mitochondrion
	Molecular Function	Motor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Glomerular Visceral Epithelial Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 31959993) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels ( 32203549)
Interacting Genes		35 interacting genes: BCL2L11 BMF C12orf40 C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HMBOX1 HOMER3 IHO1 KANK2 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 SECISBP2L SKAP1 SMCP SPAG8 THAP10 TLK1 TPPP XIAP ZAR1	185 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C11orf1 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 DYNLL2 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1
Entrez ID		140735	25959
HPRD ID		06489	12463
Ensembl ID		ENSG00000264364	ENSG00000197256
Uniprot IDs		Q96FJ2	Q63ZY3
PDB IDs		2XQQ 3P8M 4D07	4HBD 5YBV
Enriched GO Terms of Interacting Partners?
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