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KANK2 and EXOSC8
Data Source:
BioGRID
(two hybrid)
KANK2
EXOSC8
Description
KN motif and ankyrin repeat domains 2
exosome component 8
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Regulation Of Rho Protein Signal Transduction
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Vitamin D Receptor Signaling Pathway
Kidney Epithelium Development
Glomerular Visceral Epithelial Cell Migration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Biological_process
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
29212778
)
HDL cholesterol (
23505323
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Intraocular pressure (
31959993
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Triglyceride levels (
32203549
)
Interacting Genes
185 interacting genes:
ABI3
AEN
ANKRD11
AP2B1
ARL14EP
ASB15
BEND7
BIRC7
BLZF1
BORCS6
C11orf1
C2orf68
CADPS
CAMK2G
CAPN3
CARD10
CARD9
CBX8
CCDC33
CCDC57
CCDC88B
CDC20B
CDC5L
CDKL3
CEACAM6
CEP55
CEP63
CEP70
CHCHD3
CHIC2
CINP
COG6
CRX
CSNK2A1
CUTC
CWF19L2
CYTH4
DDIT4L
DLGAP3
DPEP2NB
DTX2
DYNLL1
DYNLL2
EFHC2
EIF4E
ELOA
EXOSC8
FAM161A
FAM90A1
FHL2
FHL3
FKBP6
GADD45GIP1
GATA1
GEMIN4
GKAP1
GMCL1
GMNN
GOLGA2
GOLGA6A
GOLGA6L9
GPANK1
GPKOW
GPSM1
GRB10
HAND2
HOMER3
HSF2BP
HSPB2
HSPB2-C11orf52
IHO1
IKZF3
IL16
KIF9
KIFAP3
KIFC3
KRT27
KRT34
KRT40
KRT75
KRT86
KRTAP6-3
L3MBTL3
LBX1
LENG1
LHX1
LHX3
LMO1
LMO2
LMO3
LMO4
LZTS1
MAGEB4
MCCD1
MCRS1
MED19
MEOX1
MEOX2
MID2
MITD1
MKRN3
MOB1A
MOB3C
MORN3
MSS51
MTUS2
MYOZ3
NCOA1
NCOA5
NECAB2
NOS3
NUTM1
OIP5
PAX6
PCBD1
PDE9A
PDLIM7
PFDN6
PIBF1
PLAGL2
PLEKHA2
PNKP
PPP1CB
PRDM14
PRDM6
PRKAR1B
PRMT5
PRPF18
PRPF31
PRR5L
PSEN1
PSMB4
PSTPIP1
RAB11FIP2
RALBP1
RBCK1
RHOH
SCARA5
SCNM1
SERTAD3
SNAPIN
SNW1
SORBS3
SRPK2
STAC
SYT6
TAX1BP1
TEX11
TFIP11
TGM5
THAP1
THAP6
TIFA
TLE5
TOP3B
TRAF1
TRAF2
TRAF4
TRIB3
TRIM35
TRIM54
TSGA10
TSGA10IP
TSPYL6
TXLNA
UBAP2
USHBP1
UTP14C
VMAC
VPS52
VWC2
WASF3
WASHC1
ZBTB42
ZFP57
ZMAT2
ZMYND12
ZNF212
ZNF414
ZNF512
ZNF648
ZNF774
ZNF784
ZNHIT1
ZRANB1
74 interacting genes:
AEN
ATF2
C22orf39
CCDC28A-AS1
CNNM3
COL23A1
COX5A
CRMP1
CWC22
DDIT4L
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM161B
FAM90A1
FHOD1
FOXD4L1
FOXN3
FRG1
GEM
HAPLN2
HOXB9
INCA1
KANK2
KCNJ11
LMO4
LNX1
LSM1
LSM4
LSM7
MACIR
MKRN1
MORN4
MPHOSPH6
MTREX
MYOZ1
NEDD9
NTAQ1
OTUD4
PALS2
PHF21A
PIAS2
POLDIP3
RASD1
RASSF1
REL
RFC5
RPP14
RUSC1
RXRB
SLAIN1
SNAI1
SNRPB
SNRPC
SOCS7
SPATC1L
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP2
USP6
XRN1
XRN2
ZFP36
Entrez ID
25959
11340
HPRD ID
12463
09351
Ensembl ID
ENSG00000197256
ENSG00000120699
Uniprot IDs
Q63ZY3
Q96B26
PDB IDs
4HBD
5YBV
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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