DYNLL2 and FAM117B

Data Source:
BioGRID (two hybrid)

		DYNLL2	FAM117B
Description		dynein light chain LC8-type 2	family with sequence similarity 117 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Postsynaptic Density Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Motor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 25961943) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling fed-up ( 29500382) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 25961943) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Sarcoidosis ( 26051272) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		35 interacting genes: BCL2L11 BMF C12orf40 C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HMBOX1 HOMER3 IHO1 KANK2 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 SECISBP2L SKAP1 SMCP SPAG8 THAP10 TLK1 TPPP XIAP ZAR1	6 interacting genes: AGR2 BANP DYNLL1 DYNLL2 KEAP1 STAT3
Entrez ID		140735	150864
HPRD ID		06489	12445
Ensembl ID		ENSG00000264364	ENSG00000138439
Uniprot IDs		Q96FJ2	Q6P1L5 Q7Z3M2
PDB IDs		2XQQ 3P8M 4D07
Enriched GO Terms of Interacting Partners?
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