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KANK2 and DYNLL1
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, two hybrid)
KANK2
DYNLL1
Description
KN motif and ankyrin repeat domains 2
dynein light chain LC8-type 1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Kinetochore
Nucleus
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Cytoplasmic Dynein Complex
Microtubule
Plasma Membrane
Cilium
COP9 Signalosome
Membrane
Dynein Complex
Tertiary Granule Membrane
Mitotic Spindle
Ciliary Tip
Ficolin-1-rich Granule Membrane
Axon Cytoplasm
Molecular Function
Protein Binding
Motor Activity
Enzyme Inhibitor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Nitric-oxide Synthase Regulator Activity
Identical Protein Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Dynein Light Intermediate Chain Binding
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Regulation Of Rho Protein Signal Transduction
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Vitamin D Receptor Signaling Pathway
Kidney Epithelium Development
Glomerular Visceral Epithelial Cell Migration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Apoptotic Process
Spermatid Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Macroautophagy
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Substantia Nigra Development
Intraciliary Retrograde Transport
Intraciliary Transport Involved In Cilium Assembly
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Negative Regulation Of Phosphorylation
Negative Regulation Of Catalytic Activity
Neutrophil Degranulation
Motile Cilium Assembly
Negative Regulation Of Nitric Oxide Biosynthetic Process
Cilium Assembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Non-motile Cilium Assembly
Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways
Activation of BIM and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
29212778
)
HDL cholesterol (
23505323
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Intraocular pressure (
31959993
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Triglyceride levels (
32203549
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Reading disability or specific language impairment (pleiotropy) (
25065397
)
Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) (
25065397
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
185 interacting genes:
ABI3
AEN
ANKRD11
AP2B1
ARL14EP
ASB15
BEND7
BIRC7
BLZF1
BORCS6
C11orf1
C2orf68
CADPS
CAMK2G
CAPN3
CARD10
CARD9
CBX8
CCDC33
CCDC57
CCDC88B
CDC20B
CDC5L
CDKL3
CEACAM6
CEP55
CEP63
CEP70
CHCHD3
CHIC2
CINP
COG6
CRX
CSNK2A1
CUTC
CWF19L2
CYTH4
DDIT4L
DLGAP3
DPEP2NB
DTX2
DYNLL1
DYNLL2
EFHC2
EIF4E
ELOA
EXOSC8
FAM161A
FAM90A1
FHL2
FHL3
FKBP6
GADD45GIP1
GATA1
GEMIN4
GKAP1
GMCL1
GMNN
GOLGA2
GOLGA6A
GOLGA6L9
GPANK1
GPKOW
GPSM1
GRB10
HAND2
HOMER3
HSF2BP
HSPB2
HSPB2-C11orf52
IHO1
IKZF3
IL16
KIF9
KIFAP3
KIFC3
KRT27
KRT34
KRT40
KRT75
KRT86
KRTAP6-3
L3MBTL3
LBX1
LENG1
LHX1
LHX3
LMO1
LMO2
LMO3
LMO4
LZTS1
MAGEB4
MCCD1
MCRS1
MED19
MEOX1
MEOX2
MID2
MITD1
MKRN3
MOB1A
MOB3C
MORN3
MSS51
MTUS2
MYOZ3
NCOA1
NCOA5
NECAB2
NOS3
NUTM1
OIP5
PAX6
PCBD1
PDE9A
PDLIM7
PFDN6
PIBF1
PLAGL2
PLEKHA2
PNKP
PPP1CB
PRDM14
PRDM6
PRKAR1B
PRMT5
PRPF18
PRPF31
PRR5L
PSEN1
PSMB4
PSTPIP1
RAB11FIP2
RALBP1
RBCK1
RHOH
SCARA5
SCNM1
SERTAD3
SNAPIN
SNW1
SORBS3
SRPK2
STAC
SYT6
TAX1BP1
TEX11
TFIP11
TGM5
THAP1
THAP6
TIFA
TLE5
TOP3B
TRAF1
TRAF2
TRAF4
TRIB3
TRIM35
TRIM54
TSGA10
TSGA10IP
TSPYL6
TXLNA
UBAP2
USHBP1
UTP14C
VMAC
VPS52
VWC2
WASF3
WASHC1
ZBTB42
ZFP57
ZMAT2
ZMYND12
ZNF212
ZNF414
ZNF512
ZNF648
ZNF774
ZNF784
ZNHIT1
ZRANB1
107 interacting genes:
ACTB
ACTC1
ACTG1
ALDOA
AMOTL2
B3GALT4
BCAS1
BCL2L11
BMF
C12orf40
C14orf119
C19orf44
CA2
CACNB1
CCDC28A
CLIP2
CS
DAZ1
DCTN5
DLG4
DLGAP1
DNAJB9
DNAL4
DNM2
DNM3
DNMT1
DPPA3
DYNC1H1
DYNC1I1
EEF1A1
ERG28
FAM117B
FAM153A
FAM53B
GABARAPL1
GABARAPL2
GAPDH
GLUD1
GLUL
GNL3L
GPHN
GPRIN2
GRIN3A
HIP1R
HMBOX1
HOMER3
HSPA8
IHO1
INPP1
IQUB
KANK2
LDHA
MAP1B
MARK3
MAST2
ME2
MORN3
MRE11
MTA1
MTR
MYO10
MYO5A
NDEL1
NDUFA4L2
NFKBIA
NOS1
NRF1
NTRK1
NTRK2
NTRK3
ODF3
OR7C2
OTUD6A
PAK1
PAN2
PARD3
PAX6
PCM1
PFKM
PFKP
PKIA
PKIB
PKIG
POLH
PPP3R2
RAB4A
RACK1
RASGRP4
RGS2
SHROOM3
SLC13A1
SMCP
TERT
THAP10
THAP8
TNFRSF14
TP53BP1
TRIM54
TSNARE1
TUBA3C
TUBB
TXNDC17
VIM
ZHX1
ZMYND11
ZNF354A
ZNF710
Entrez ID
25959
8655
HPRD ID
12463
03334
Ensembl ID
ENSG00000197256
ENSG00000088986
Uniprot IDs
Q63ZY3
P63167
Q6FGH9
PDB IDs
4HBD
5YBV
1CMI
3ZKE
3ZKF
6GZJ
6GZL
6RLB
6SC2
Enriched GO Terms of Interacting Partners
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