ACAN and MMP19

Data Source:
HPRD (in vitro)

		ACAN	MMP19
Description		aggrecan	matrix metallopeptidase 19
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Keratan Sulfate Catabolic Process	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteolysis Proteolysis Response To Hormone Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Collagen Catabolic Process Response To CAMP
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix
Drugs		Ilomastat	Marimastat
Diseases		Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Advanced age-related macular degeneration ( 26691988) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR	1 interacting genes: ACAN
Entrez ID		176	4327
HPRD ID		01123	03486
Ensembl ID		ENSG00000157766	ENSG00000123342
Uniprot IDs		P16112	Q99542
PDB IDs		4MD4
Enriched GO Terms of Interacting Partners?
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