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CBL and ITK
Data Source:
HPRD
(in vitro, in vivo)
CBL
ITK
Description
Cbl proto-oncogene
IL2 inducible T cell kinase
Image
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Flotillin Complex
Growth Cone
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Molecular Function
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Entry Of Bacterium Into Host Cell
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Antibiotic
Positive Regulation Of Receptor-mediated Endocytosis
Membrane Organization
Interleukin-6-mediated Signaling Pathway
Neuron Death
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Oxygen-glucose Deprivation
Negative Regulation Of Neuron Death
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Cellular Defense Response
Signal Transduction
Activation Of Phospholipase C Activity
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Activation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Pathways
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Drugs
Staurosporine
Pazopanib
Fostamatinib
Zanubrutinib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
22139419
29403010
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Asthma (
31959851
)
Daytime sleep phenotypes (
27126917
)
Eosinophil counts (
32888494
)
Heel bone mineral density (
30598549
)
Personality traits in bipolar disorder (
21368711
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Interacting Genes
128 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PRKCA
PRKCQ
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TNS4
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
34 interacting genes:
BLNK
BMX
BTK
CBL
CD28
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FYN
GAB1
GRB2
HNRNPK
IKBKG
KHDRBS1
KPNA2
LAT
LCK
LCP2
MET
PLCG1
PLCG2
PPIA
SH2D2A
SMAD4
SMURF1
SOCS1
SPRR2A
SRC
TGFBR1
WAS
Entrez ID
867
3702
HPRD ID
01320
01746
Ensembl ID
ENSG00000110395
ENSG00000113263
Uniprot IDs
P22681
Q08881
PDB IDs
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
1SM2
1SNU
1SNX
2E6I
2LMJ
2YUQ
3MIY
3MJ1
3MJ2
3QGW
3QGY
3T9T
3V5J
3V5L
3V8T
3V8W
4HCT
4HCU
4HCV
4KIO
4L7S
4M0Y
4M0Z
4M12
4M13
4M14
4M15
4MF0
4MF1
4PP9
4PPA
4PPB
4PPC
4PQN
4QD6
4RFM
Enriched GO Terms of Interacting Partners
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