OTOL1 and TRIM59

Data Source:
BioGRID (two hybrid)

		OTOL1	TRIM59
Description		otolin 1	tripartite motif containing 59
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Extracellular Space Extracellular Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Otolith Mineralization Protein Homooligomerization	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Aging (time to death) ( 21782286) Alcohol consumption (drinks per week) ( 30643258) Hepcidin/ferritin ratio ( 27846281) Schizophrenia ( 28991256 30285260) Type 2 diabetes ( 30130595)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes			26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		131149	286827
HPRD ID		19083	15568
Ensembl ID		ENSG00000182447	ENSG00000213186
Uniprot IDs		A6NHN0	Q8IWR1
PDB IDs
Enriched GO Terms of Interacting Partners?
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