JOSD2 and TTPA

Data Source:
BioGRID (two hybrid)

		JOSD2	TTPA
Description		Josephin domain containing 2	alpha tocopherol transfer protein
Image
GO Annotations	Cellular Component	Cytosol	Late Endosome Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation	Lipid Metabolic Process Response To Nutrient Response To PH Developmental Process Vitamin E Metabolic Process Vitamin Transport Intracellular PH Reduction Negative Regulation Of Cell Death Intermembrane Lipid Transfer
Pathways		Josephin domain DUBs	Vitamin E
Drugs
Diseases			Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS
Interacting Genes		13 interacting genes: AHCYL1 CMTM5 COQ8A FKBP7 MDK PLA2G2A STUB1 SYP TRAPPC2 TRAPPC2B TTPA UBC YIF1A	46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52
Entrez ID		126119	7274
HPRD ID		15297	02685
Ensembl ID		ENSG00000161677	ENSG00000137561
Uniprot IDs		A0A024R4G2 Q7Z7N5 Q8TAC2	P49638
PDB IDs		6PGV	1OIP 1OIZ 1R5L 5MUE 5MUG
Enriched GO Terms of Interacting Partners?
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