TTPA and COQ3

Data Source:
BioGRID (two hybrid)

		TTPA	COQ3
Description		alpha tocopherol transfer protein	coenzyme Q3, methyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Late Endosome Cytosol	Mitochondrion Mitochondrial Matrix Extrinsic Component Of Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Hexaprenyldihydroxybenzoate Methyltransferase Activity Protein Binding O-methyltransferase Activity 2-polyprenyl-6-methoxy-1,4-benzoquinone Methyltransferase Activity 3-demethylubiquinone-9 3-O-methyltransferase Activity Decaprenyldihydroxybenzoate Methyltransferase Activity 3-demethylubiquinol-10 3-O-methyltransferase Activity
	Biological Process	Lipid Metabolic Process Response To Nutrient Response To PH Developmental Process Vitamin E Metabolic Process Vitamin Transport Intracellular PH Reduction Negative Regulation Of Cell Death Intermembrane Lipid Transfer	Glycerol Metabolic Process Ubiquinone Biosynthetic Process Regulation Of Ubiquinone Biosynthetic Process Methylation
Pathways		Vitamin E	Ubiquinol biosynthesis
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS			Regular attendance at a religious group ( 29970889)
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	4 interacting genes: NDRG4 PTPN9 SNX1 TTPA
Entrez ID		7274	51805
HPRD ID		02685	07283
Ensembl ID		ENSG00000137561	ENSG00000132423
Uniprot IDs		P49638	Q9NZJ6
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG
Enriched GO Terms of Interacting Partners?
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