CMKLR1 and TPST1

Data Source:
HPRD (in vitro)

		CMKLR1	TPST1
Description		chemerin chemokine-like receptor 1	tyrosylprotein sulfotransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Golgi Membrane
	Molecular Function	Complement Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Signaling Receptor Activity	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity
	Biological Process	Skeletal System Development Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fat Cell Differentiation Regulation Of Calcium-mediated Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Peptidyl-tyrosine Sulfation Inflammatory Response Protein Phosphopantetheinylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Pathways		Class A/1 (Rhodopsin-like receptors)	Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 22688191) Erectile dysfunction and prostate cancer treatment ( 20932654) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Protein level change in low calorie diet obesity intervention ( 29234017) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 21483023) Risk-taking tendency (4-domain principal component model) ( 30643258)	Blood protein levels ( 30072576 29875488) Gout ( 22179738)
Interacting Genes		2 interacting genes: TPST1 TPST2	6 interacting genes: CCR1 CCR8 CMKLR1 GP1BA GPR1 SELPLG
Entrez ID		1240	8460
HPRD ID		03829	07216
Ensembl ID		ENSG00000174600	ENSG00000169902
Uniprot IDs		Q99788	A0A024RDK9 O60507
PDB IDs			5WRI 5WRJ
Enriched GO Terms of Interacting Partners?
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