NEDD1 and RND1

Data Source:
BioGRID (two hybrid)

		NEDD1	RND1
Description		NEDD1 gamma-tubulin ring complex targeting factor	Rho family GTPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Nucleoplasm Centrosome Centriole Cytosol Plasma Membrane Ciliary Basal Body Apical Part Of Cell	Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking	Actin Filament Organization Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Neuron Remodeling Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism ( 24189344) Breast size ( 22747683) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Manganese levels ( 26025379)	Bipolar disorder ( 21926972)
Interacting Genes		3 interacting genes: EP300 FBLN1 RND1	23 interacting genes: ARFIP2 ARHGAP5 CCNI COPS2 CREB3L2 EEF1A1 FRS2 FRS3 GPX8 GRB7 ID3 MYH7 MYOM3 MYZAP NEDD1 PAIP1 PDE6D PLXNA1 PLXNB1 PLXNB2 RAI14 UBXN11 ZNF212
Entrez ID		121441	27289
HPRD ID		02655	12357
Ensembl ID		ENSG00000139350	ENSG00000172602
Uniprot IDs		A0A024RBE5 A8K1Z3 Q8NHV4	Q92730
PDB IDs			2CLS 2REX 3Q3J
Enriched GO Terms of Interacting Partners?
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