CLTB and HTR4

Data Source:
BioGRID (two hybrid)

		CLTB	HTR4
Description		clathrin light chain B	5-hydroxytryptamine receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Cytoplasmic Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding
	Biological Process	Intracellular Protein Transport Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Obesity-related traits ( 23251661)	Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)
Interacting Genes		9 interacting genes: CALM1 CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		1212	3360
HPRD ID		00352	09074
Ensembl ID		ENSG00000175416	ENSG00000164270
Uniprot IDs		A0A024R7S3 P09497	A0A2D3FAF9 Q13639
PDB IDs			5EM9
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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