SFR1 and RNF40

Data Source:
BioGRID (two hybrid)

		SFR1	RNF40
Description		SWI5 dependent homologous recombination repair protein 1	ring finger protein 40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Swi5-Sfr1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Membrane Extrinsic Component Of Membrane HULC Complex Neuron Projection Axon Terminus
	Molecular Function	Protein Binding Nuclear Receptor Coactivator Activity	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Syntaxin-1 Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Transcription, DNA-templated Cellular Response To Estrogen Stimulus	Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Protein Ubiquitination Histone H2B Ubiquitination Response To Peptide Hormone Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Histone H2B Ubiquitination
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		15 interacting genes: CDC5L CEP70 DTNBP1 EXOC1 FBXO7 HMBOX1 MRFAP1L1 NDC80 NMI RAD51 RINT1 RNF40 SWI5 TFIP11 TRAF3IP1	26 interacting genes: AMOTL2 ATM CCDC146 CDC73 DISC1 DUSP29 EEF1D ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL RB1 RNF20 SFR1 TRIM51 UBE2A UBE2B UBE2D2 UBE2E1 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		119392	9810
HPRD ID		12590	07411
Ensembl ID		ENSG00000156384	ENSG00000103549
Uniprot IDs		Q86XK3	A8K6K1 O75150
PDB IDs
Enriched GO Terms of Interacting Partners?
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