HOMER1 and GRM1

Data Source:
HPRD (in vitro)

		HOMER1	GRM1
Description		homer scaffold protein 1	glutamate metabotropic receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Z Disc Axon Dendrite Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Glutamatergic Synapse Postsynaptic Cytosol	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Ion Channel Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Postsynaptic Neurotransmitter Receptor Activity Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity	Activation Of MAPKK Activity Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		Neurexins and neuroligins Neurexins and neuroligins	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs			Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases
GWAS		Bipolar disorder ( 31043756) Blood and toenail selenium levels ( 25343990) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)	Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)
Interacting Genes		34 interacting genes: ABI1 ABI3 AGAP2 AIMP1 BRME1 C1orf116 CENPQ DBNL DNM3 EFNB2 FAM9A FAT1 FCHSD2 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 NUP54 PATJ PIAS2 RAD54L2 RASAL3 RYR1 RYR2 SHANK1 SHANK2 STX12 SYCE2 TANC1 TRAF5 TRPC1 ZMYM5	40 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB
Entrez ID		9456	2911
HPRD ID		09211	05129
Ensembl ID		ENSG00000152413	ENSG00000152822
Uniprot IDs		Q5U5K4 Q86YM7	Q13255 Q59HC2
PDB IDs			3KS9 4OR2
Enriched GO Terms of Interacting Partners?
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