ARAP1 and ARPC3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARAP1	ARPC3
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	actin related protein 2/3 complex subunit 3
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GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus
Pathways		Rho GTPase cycle PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body mass index ( 28892062 25673413) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)	Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6	30 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		116985	10094
HPRD ID		09440	09175
Ensembl ID		ENSG00000186635	ENSG00000111229
Uniprot IDs		Q96P48	O15145
PDB IDs		4X1V	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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