ARAP1 and PSD3

Data Source:
BioGRID (two hybrid)

		ARAP1	PSD3
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	pleckstrin and Sec7 domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle	Postsynaptic Density Ruffle Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Rho GTPase cycle PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body mass index ( 28892062 25673413) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)	Body fat mass ( 28552196) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Bone ultrasound measurement (velocity of sound) ( 28472463) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery disease ( 33020668) Erythrocyte cadmium concentration in never smokers ( 27005419) Glucose homeostasis traits ( 30576415) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longitudinal cocaine use ( 31591132) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Paclitaxel-induced neuropathy ( 23776197) Perceived intensity of fructose ( 31005972) Schizophrenia ( 30285260) Sub-cortical grey matter volume ( 31530798) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Trunk fat mass ( 28552196) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)
Interacting Genes		14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6	2 interacting genes: ARAP1 MX1
Entrez ID		116985	23362
HPRD ID		09440	11462
Ensembl ID		ENSG00000186635	ENSG00000156011
Uniprot IDs		Q96P48	B3KRC4 Q9NYI0
PDB IDs		4X1V
Enriched GO Terms of Interacting Partners?
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