ARAP1 and KCTD12

Data Source:
BioGRID (two hybrid)

		ARAP1	KCTD12
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	potassium channel tetramerization domain containing 12
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GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle	Presynaptic Membrane Cell Projection Postsynaptic Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Protein Homooligomerization
Pathways		Rho GTPase cycle PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body mass index ( 28892062 25673413) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)	Incident chronic kidney disease ( 30955190) Response to fenofibrate (triglyceride levels) ( 27002377) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6	3 interacting genes: ARAP1 GABBR2 ZNF792
Entrez ID		116985	115207
HPRD ID		09440	11060
Ensembl ID		ENSG00000186635	ENSG00000178695
Uniprot IDs		Q96P48	A0A140VJM4 Q96CX2
PDB IDs		4X1V	6M8S 6QZL
Enriched GO Terms of Interacting Partners?
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