ADCYAP1 and CASP2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ADCYAP1	CASP2
Description		adenylate cyclase activating polypeptide 1	caspase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Terminal Bouton Perikaryon	Nucleus Cytoplasm Mitochondrion Cytosol Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Insulin Secretion Neuron Projection Development Positive Regulation Of Interleukin-6 Production Regulation Of Protein Localization Negative Regulation Of GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II ATP Metabolic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Somatostatin Secretion Positive Regulation Of Cold-induced Thermogenesis	Luteolysis Neural Retina Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs		2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		8 interacting genes: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	31 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		116	835
HPRD ID		02369	02800
Ensembl ID		ENSG00000141433	ENSG00000106144
Uniprot IDs		B7Z222 P18509	A0A087WYM1 A0A0S2Z3H1 D3DXD9 P42575
PDB IDs		1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD
Enriched GO Terms of Interacting Partners?
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