ADCYAP1 and SCTR

Data Source:
BioGRID (unspecified method, unspecified method)
HPRD (in vivo, in vitro)

		ADCYAP1	SCTR
Description		adenylate cyclase activating polypeptide 1	secretin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Terminal Bouton Perikaryon	Cytoplasmic Microtubule Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Insulin Secretion Neuron Projection Development Positive Regulation Of Interleukin-6 Production Regulation Of Protein Localization Negative Regulation Of GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II ATP Metabolic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Somatostatin Secretion Positive Regulation Of Cold-induced Thermogenesis	Diet Induced Thermogenesis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Brain Development Cellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Positive Regulation Of CAMP-mediated Signaling Regulation Of Synaptic Plasticity
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		2,6-Diamino-Hexanoic Acid Amide	Secretin human
Diseases
GWAS		Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Bipolar disorder ( 31043756) Type 2 diabetes ( 32499647 30718926)
Interacting Genes		8 interacting genes: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1
Entrez ID		116	6344
HPRD ID		02369	01628
Ensembl ID		ENSG00000141433	ENSG00000080293
Uniprot IDs		B7Z222 P18509	P47872 Q8IV17
PDB IDs		1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7	6WI9 6WZG 7D3S
Enriched GO Terms of Interacting Partners?
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