FCHO2 and DAB2

Data Source:
BioGRID (pull down)

		FCHO2	DAB2
Description		FCH and mu domain containing endocytic adaptor 2	DAB adaptor protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle Presynaptic Endocytic Zone Membrane	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding Identical Protein Binding	Protein Binding Protein C-terminus Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Integrin-mediated Signaling Pathway Multicellular Organism Development Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 32888494 27863252) Serum albumin level ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Birth weight ( 31043758) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)
Interacting Genes		6 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 RHOU UBC	40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2
Entrez ID		115548	1601
HPRD ID		13319	03139
Ensembl ID		ENSG00000157107	ENSG00000153071
Uniprot IDs		Q0JRZ9	A0A024R036 B2RAW0 P98082
PDB IDs		2V0O	2LSW 6O5O 6OVF
Enriched GO Terms of Interacting Partners?
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