BUD23 and PKN1

Data Source:
BioGRID (two hybrid)

		BUD23	PKN1
Description		BUD23 rRNA methyltransferase and ribosome maturation factor	protein kinase N1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Protein Heterodimerization Activity	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Nuclear Receptor Coactivator Activity Small GTPase Binding Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Androgen Receptor Binding
	Biological Process	Chromatin Organization RRNA Methylation RRNA (guanine-N7)-methylation Positive Regulation Of RRNA Processing	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Spleen Development Regulation Of Cell Motility
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs			Fostamatinib
Diseases
GWAS			Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		4 interacting genes: OAS1 PKN1 TRMT112 VCP	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC103 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TRIM27 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		114049	5585
HPRD ID		15659	03019
Ensembl ID		ENSG00000071462	ENSG00000123143
Uniprot IDs		O43709	Q16512
PDB IDs		6G4W	1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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