TMEM106A and TSPAN4

Data Source:
BioGRID (two hybrid)

		TMEM106A	TSPAN4
Description		transmembrane protein 106A	tetraspanin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Vesicle
	Molecular Function	Molecular_function Protein Binding	Antigen Binding Integrin Binding Protein Binding
	Biological Process	Biological_process Interleukin-1 Beta Production Interleukin-6 Production Tumor Necrosis Factor Production CD80 Biosynthetic Process CD86 Biosynthetic Process Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process	Protein-containing Complex Assembly
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Falling risk ( 32999390)
Interacting Genes		13 interacting genes: ARF1 ENTPD3 ERG28 GJB2 GOSR2 IGFBP5 RHOU TMEM106C TMEM107 TMEM128 TMEM86B TNMD TSPAN4	49 interacting genes: CATSPER1 CD46 CD81 CD9 CHRD CLDN11 CLEC2D CREB3 CREB5 CYSRT1 EVA1A FCHO1 FRS3 GNE GRN GUCD1 HOXA1 ITGA3 ITGA6 ITGB1 KRTAP10-1 KRTAP10-8 KRTAP4-11 KRTAP4-5 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE2B LCE2D LCE3A LCE3C LCE3D LCE4A LRRC25 LTB4R2 MDFI MGAT5B MKRN3 NBPF19 NOTCH2NLA NR4A3 OTX1 PHLDA1 PLSCR4 SGPL1 TEKT4 TMEM106A VGLL3
Entrez ID		113277	7106
HPRD ID		11315	04033
Ensembl ID		ENSG00000184988	ENSG00000214063
Uniprot IDs		B7Z779 Q96A25	A0A024RCE1 A8MVV6 O14817
PDB IDs
Enriched GO Terms of Interacting Partners?
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