CHN1 and CDK5R1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CHN1	CDK5R1
Description		chimerin 1	cyclin dependent kinase 5 regulatory subunit 1
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding Ephrin Receptor Binding	Protease Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Motor Neuron Axon Guidance Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Microtubule Polymerization Neuron Projection Development Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Serine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Regulation Of Synaptic Vesicle Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Rho GTPase cycle	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5
Drugs			Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases		Duane retraction syndrome
GWAS		Post bronchodilator FEV1 ( 26634245)
Interacting Genes		16 interacting genes: ACVR1 ADORA2A ANKK1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 HTR6 MAPK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1	31 interacting genes: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		1123	8851
HPRD ID		00319	04586
Ensembl ID		ENSG00000128656	ENSG00000176749
Uniprot IDs		P15882	Q15078 Q8N619
PDB IDs		2OSA 3CXL	1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG
Enriched GO Terms of Interacting Partners?
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