SSRP1 and NEK9

Data Source:
HPRD (in vivo)

		SSRP1	NEK9
Description		structure specific recognition protein 1	NIMA related kinase 9
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus FACT Complex	Nucleus Centrosome Cytosol
	Molecular Function	DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Replication DNA Repair Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Chromatin Organization	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS			Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		22 interacting genes: AURKA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AC20 H2AX H2BC21 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 SUPT16H UBE2I	10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN
Entrez ID		6749	91754
HPRD ID		05061	11386
Ensembl ID		ENSG00000149136	ENSG00000119638
Uniprot IDs		A0A024R4Z6 Q08945	Q6PKF2 Q8TD19
PDB IDs		4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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