LSM6 and PATL1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		LSM6	PATL1
Description		LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated	PAT1 homolog 1, processing body mRNA decay factor
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex	P-body Cytosol PML Body Nuclear Speck CCR4-NOT Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Binding Protein Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Poly(U) RNA Binding Poly(G) Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA Exonucleolytic Catabolism Of Deadenylated MRNA	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs		Uridine Uridine monophosphate Citric acid
Diseases
GWAS		Malaria ( 31844061) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		16 interacting genes: APP CLNS1A LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 PATL1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	20 interacting genes: APP FHL3 GOLGA2 KRTAP6-2 LSM2 LSM6 MIR1-2 MIR138-2 MIR15B MIR19B1 MIR19B2 MIR20B MIR21 MIR25 MIR29B2 NFKBID PSMA3 TSC1 WWOX ZMYND12
Entrez ID		11157	219988
HPRD ID		06286	08214
Ensembl ID		ENSG00000164167	ENSG00000166889
Uniprot IDs		P62312	Q86TB9
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	2XEQ 2XER 2XES
Enriched GO Terms of Interacting Partners?
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