LSM6 and LSM3

Data Source:
BioGRID (biochemical, affinity chromatography technology, two hybrid)
HPRD (in vitro)

		LSM6	LSM3
Description		LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	RNA Binding Protein Binding Protein Heterodimerization Activity	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA Exonucleolytic Catabolism Of Deadenylated MRNA	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs		Uridine Uridine monophosphate Citric acid
Diseases
GWAS		Malaria ( 31844061) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APP CLNS1A LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 PATL1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		11157	27258
HPRD ID		06286	06283
Ensembl ID		ENSG00000164167	ENSG00000170860
Uniprot IDs		P62312	P62310
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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