LDB3 and MYOZ1

Data Source:
HPRD (two hybrid, in vivo)

		LDB3	MYOZ1
Description		LIM domain binding 3	myozenin 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoskeleton Adherens Junction Z Disc Pseudopodium Filamentous Actin Perinuclear Region Of Cytoplasm	Nucleus Actin Cytoskeleton Z Disc Pseudopodium
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding FATZ Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Sarcomere Organization Muscle Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Negative Regulation Of Phosphoprotein Phosphatase Activity Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		7 interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53	40 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FLNA FLNC GOLGA6A GRB2 KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3
Entrez ID		11155	58529
HPRD ID		16172	05725
Ensembl ID		ENSG00000122367	ENSG00000177791
Uniprot IDs		A0A0S2Z501 A0A0S2Z530 O75112	Q9NP98
PDB IDs		1RGW 4YDP
Enriched GO Terms of Interacting Partners?
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