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PRSS23 and ACTG1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PRSS23
ACTG1
Description
serine protease 23
actin gamma 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum Lumen
Extracellular Exosome
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Apical Junction Complex
Extracellular Exosome
Blood Microparticle
Dense Body
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Profilin Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Biological Process
Proteolysis
Post-translational Protein Modification
Cellular Protein Metabolic Process
Angiogenesis
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Cell Junction Assembly
Maintenance Of Blood-brain Barrier
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Ephrin Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Membrane Organization
Platelet Aggregation
Positive Regulation Of Wound Healing
Postsynaptic Actin Cytoskeleton Organization
Tight Junction Assembly
Regulation Of Transepithelial Transport
Protein Localization To Bicellular Tight Junction
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
Copper
Artenimol
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Chronic obstructive pulmonary disease (
30804561
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
28869591
)
Intraocular pressure (
29617998
29785010
)
Lung function (FEV1) (
28166213
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Hand grip strength (
29313844
)
Refractive error (
32231278
)
Interacting Genes
26 interacting genes:
ACTG1
APP
B2M
CHP1
EFNA3
FXR1
GATD1
GRK6
HSPA4
MAPK8IP2
NCAPD3
NIPBL
NOC4L
ODF2L
PDPK1
PHF23
PPIA
RACGAP1
RECQL4
RPL4P5
SEC11C
SHMT1
SLC25A6
TCF12
TMEM222
TRAPPC4
68 interacting genes:
ABLIM1
ACTB
ANXA5
ATF7IP
BCAP31
BIN1
BRCA1
CAP1
CAP2
CAPZA3
CCDC22
CDC37
CDKN2A
CFL1
CFL2
COTL1
CTBP2
CTTN
CYBB
DISC1
DNASE1
DSTN
DUX4
DYNLL1
EHHADH
EIF6
FHOD1
FPR1
GIT2
GSN
GZMA
GZMK
HRAS
HSPB2
LGALS13
LIG4
LINC01554
LSP1
MAP1A
MAPK6
MAPT
MCPH1
MYO1A
MYOC
NDRG1
NR3C2
NTAQ1
PFN2
PLD1
PLEC
PPP1R9A
PRSS23
PSEN2
PTPRO
RPS6KA5
SCIN
SH3GL2
SRPK2
ST3GAL3
SUMO4
TMSB4X
TMSB4Y
TNIK
VASP
VIL1
WASF1
WASL
WIPF1
Entrez ID
11098
71
HPRD ID
07149
00017
Ensembl ID
ENSG00000150687
ENSG00000184009
Uniprot IDs
O95084
P63261
PDB IDs
5JLH
6CXI
6CXJ
6G2T
6V62
6V63
6WK1
6WK2
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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