CHAT and PRKCG

Data Source:
HPRD (in vitro)

		CHAT	PRKCG
Description		choline O-acetyltransferase	protein kinase C gamma
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Neuron Projection Presynapse	Nucleus Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Dendrite Calyx Of Held Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Choline O-acetyltransferase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Phosphatidylcholine Biosynthetic Process Neurotransmitter Secretion Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process	Protein Phosphorylation Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Phosphorylation Peptidyl-serine Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Response To Pain Rhythmic Process Regulation Of Phagocytosis Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Protein Catabolic Process Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		Synthesis of PC Acetylcholine Neurotransmitter Release Cycle	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs		Nicotine	Tamoxifen Fostamatinib
Diseases		Congenital myasthenic syndrome	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)
Interacting Genes		9 interacting genes: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ	64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DDX58 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		1103	5582
HPRD ID		07510	01502
Ensembl ID		ENSG00000070748	ENSG00000126583
Uniprot IDs		D3DX95 P28329 Q6LEN5 Q6LEN6	B2R5T1 B7Z3W6 P05129
PDB IDs		2FY2 2FY3 2FY4 2FY5 7AMD	2E73 2UZP
Enriched GO Terms of Interacting Partners?
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