EHD1 and RFFL

Data Source:
BioGRID (enzymatic study)

		EHD1	RFFL
Description		EH domain containing 1	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Lipid Droplet Plasma Membrane Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Platelet Dense Tubular Network Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Calcium Ion Binding Protein Binding ATP Binding GTP Binding Small GTPase Binding Identical Protein Binding Cadherin Binding	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Cholesterol Storage Endosomal Transport Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Factors involved in megakaryocyte development and platelet production	Regulation of TP53 Degradation
Drugs
Diseases
GWAS			Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		13 interacting genes: ANKFY1 AP2A1 EHBP1 EHD3 HSPB1 IGF1R MICAL1 MICALL1 MUL1 RAB11FIP2 RBSN RFFL SNAP29	21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		10938	117584
HPRD ID		09325	11489
Ensembl ID		ENSG00000110047	ENSG00000092871
Uniprot IDs		A0A024R571 B2R5U3 Q9H4M9	Q8WZ73
PDB IDs		2JQ6 2KFF 2KFG 2KFH 2KSP	1Y02
Enriched GO Terms of Interacting Partners?
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