COPS8 and GPS1

Data Source:
HPRD (in vitro)

		COPS8	GPS1
Description		COP9 signalosome subunit 8	G protein pathway suppressor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Cytosol COP9 Signalosome
	Molecular Function	Protein Binding	GTPase Inhibitor Activity Protein Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Post-translational Protein Modification	Inactivation Of MAPK Activity Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair JNK Cascade Negative Regulation Of GTPase Activity Post-translational Protein Modification
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)
Interacting Genes		17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 USHBP1	29 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 ELOB IP6K1 ITPK1 RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL
Entrez ID		10920	2873
HPRD ID		16737	15991
Ensembl ID		ENSG00000198612	ENSG00000169727
Uniprot IDs		A0A024R4D1 Q99627	A0A096LP07 A0A096LPJ3 C9JFE4 Q13098
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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