CYP46A1 and RIN3

Data Source:
BioGRID (two hybrid)

		CYP46A1	RIN3
Description		cytochrome P450 family 46 subfamily A member 1	Ras and Rab interactor 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Dendrite Presynapse Postsynapse	Cytoplasm Early Endosome Cytosol Endocytic Vesicle Axon Dendrite Cytoplasmic Vesicle Vesicle Neuronal Cell Body
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Cholesterol 24-hydroxylase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Xenobiotic Metabolic Process Nervous System Development Sterol Metabolic Process Progesterone Metabolic Process Regulation Of Long-term Synaptic Potentiation Protein Localization To Membrane Raft	Negative Regulation Of Receptor Internalization Endocytosis Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Copper levels ( 26025379) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Pulse pressure ( 27841878) Scalp hair shape ( 26926045)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Appendicular lean mass ( 33097823) Asthma ( 32296059) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paget's disease ( 21623375) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)
Interacting Genes		4 interacting genes: CLK1 RIN3 TRIM55 TRIM63	41 interacting genes: ASB3 ASB8 BIN1 CRK CRKL CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71
Entrez ID		10858	79890
HPRD ID		04970	11494
Ensembl ID		ENSG00000036530	ENSG00000100599
Uniprot IDs		Q9Y6A2	Q6NSK7 Q6ZRC2 Q86U22 Q8TB24
PDB IDs		2Q9F 2Q9G 3MDM 3MDR 3MDT 3MDV 4ENH 4FIA 4J14	3U23 4WCI
Enriched GO Terms of Interacting Partners?
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