RIN3 and CSRP3

Data Source:
BioGRID (two hybrid)

		RIN3	CSRP3
Description		Ras and Rab interactor 3	cysteine and glycine rich protein 3
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endocytic Vesicle Axon Dendrite Cytoplasmic Vesicle Vesicle Neuronal Cell Body	Nucleus Cytoplasm Cytoskeleton Z Disc
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Telethonin Binding Identical Protein Binding Actinin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Receptor Internalization Endocytosis Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size	Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis Inflammatory Response Skeletal Muscle Tissue Development Insulin Receptor Signaling Pathway Actin Cytoskeleton Organization T-tubule Organization Protein Localization To Organelle Detection Of Muscle Stretch Glucose Homeostasis Sarcomere Organization Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Cardiac Muscle Contraction Muscle Tissue Development Protein Kinase C Signaling Regulation Of Protein Localization To Plasma Membrane
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Appendicular lean mass ( 33097823) Asthma ( 32296059) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paget's disease ( 21623375) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)	Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Red blood cell count ( 32888494 27863252)
Interacting Genes		41 interacting genes: ASB3 ASB8 BIN1 CRK CRKL CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71	11 interacting genes: ACTN1 FHL1 HDAC4 LDHD LIMS1 MYF6 MYOD1 MYOG NHLH1 RIN3 SPTB
Entrez ID		79890	8048
HPRD ID		11494	07525
Ensembl ID		ENSG00000100599	ENSG00000129170
Uniprot IDs		Q6NSK7 Q6ZRC2 Q86U22 Q8TB24	A2TDB8 P50461
PDB IDs		3U23 4WCI	2O10 2O13
Enriched GO Terms of Interacting Partners?
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