RIN3 and ASB8

Data Source:
BioGRID (two hybrid)

		RIN3	ASB8
Description		Ras and Rab interactor 3	ankyrin repeat and SOCS box containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endocytic Vesicle Axon Dendrite Cytoplasmic Vesicle Vesicle Neuronal Cell Body	Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Negative Regulation Of Receptor Internalization Endocytosis Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size	Protein Ubiquitination Intracellular Signal Transduction Post-translational Protein Modification
Pathways		RAB GEFs exchange GTP for GDP on RABs	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Appendicular lean mass ( 33097823) Asthma ( 32296059) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paget's disease ( 21623375) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)
Interacting Genes		41 interacting genes: ASB3 ASB8 BIN1 CRK CRKL CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71	6 interacting genes: ELOB HOXD4 MCM7 RCN1 RIN3 SERTAD1
Entrez ID		79890	140461
HPRD ID		11494	10675
Ensembl ID		ENSG00000100599	ENSG00000177981
Uniprot IDs		Q6NSK7 Q6ZRC2 Q86U22 Q8TB24	F5GYF0 Q9H765
PDB IDs		3U23 4WCI
Enriched GO Terms of Interacting Partners?
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