RIN3 and BIN1

Data Source:
HPRD (in vitro, two hybrid)

		RIN3	BIN1
Description		Ras and Rab interactor 3	bridging integrator 1
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endocytic Vesicle Axon Dendrite Cytoplasmic Vesicle Vesicle Neuronal Cell Body	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Lipid Tube
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Protease Binding Protein Binding Phospholipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Tau Protein Binding Actin Filament Binding Chaperone Binding RNA Polymerase Binding
	Biological Process	Negative Regulation Of Receptor Internalization Endocytosis Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Mast Cell Chemotaxis Regulation Of Vesicle Size	Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Viral Process Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Nucleus Localization Lipid Tube Assembly Membrane Organization Regulation Of Cell Cycle Arrest Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		RAB GEFs exchange GTP for GDP on RABs	Clathrin-mediated endocytosis
Drugs
Diseases			Centronuclear myopathy
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Appendicular lean mass ( 33097823) Asthma ( 32296059) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paget's disease ( 21623375) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)	Alzheimer's disease ( 22832961 21460840 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 21390209 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)
Interacting Genes		41 interacting genes: ASB3 ASB8 BIN1 CRK CRKL CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71	46 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3
Entrez ID		79890	274
HPRD ID		11494	03150
Ensembl ID		ENSG00000100599	ENSG00000136717
Uniprot IDs		Q6NSK7 Q6ZRC2 Q86U22 Q8TB24	A0A024RAE9 A0A024RAF0 A0A024RAF1 A0A024RAF6 A0A024RAG8 A0A024RAG9 A0A024RAI4 A0A024RAI5 A0A024RAI6 A0A024RAJ2 A0A024RAJ3 B7Z2Z2 B7Z6Y2 O00499 Q9BTH3
PDB IDs		3U23 4WCI	1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22
Enriched GO Terms of Interacting Partners?
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